Given the millions and millions of known organic compounds with diverse structural features and constraints, not to mention the virtually unlimited number of compounds organic chemists can imagine, it is impossible to construct a flow chart that can guide the student to determine whether a given molecule is chiral or achiral and works for each and every molecule.  The following flow chart works for most compounds undergraduates encounter in lower-level organic chemistry classes and would at least provide a foundation upon which unusual or more complex molecules can be analyzed,  It assumes that the molecule contains no heteroatom chiral centers.

i.